Meet AdmixLab. A DIY tool powered by qpAdm
Enjoy complete freedom… We provide you with powerful scientific tools—commonly used in population genetics research—so you can conduct your own experiments on the comfort of your web browser.
Datasets & Targets
- Upload your own raw data files and use them with large datasets. Our non-destructive merging pipelines ensure seamless integration.
- Or use any sample in the dataset as a target. You have complete freedom!
Features
- Model multiple targets simultaneously
- Use population groups, modify the groups or use individual samples with a single click
- Easily search & select thousands of samples, instantly browse their meta informations like SNP counts, dates, haplogroups and more
- Create population presets for references and sources to use them quickly later
- Download Raw Outputs of each analysis for full details
- Save your analysis in folders for future reference
- Documentation ready. Each step is explained in detail to get you up and running quickly
Extras: FST Distances
Calculate genetic distances between populations using the FST (Fixation idex) method. FST is the most common method used in populations genetics to estimate genetic distances between populations. It is now accesible to you as well!
Q & A
Admix Lab is a browser based enviroment service for the tool called qpAdm (and FST), a popular software often used in scientific studies for estimating admixture/ancestry proportions of populations.
AdmixLab is a DIY (Do It Yourself) service, meaning there are no pre-generated results—you'll need to build your own models. We've made the process straightforward with easy-to-follow steps, a user-friendly interface, and detailed documentation on how to use the tool and interpret your results.
However, a basic understanding of population genetics and ancient DNA literature is still required. At a minimum, you should know which samples to select in order to construct a meaningful model. Because of the nature of the tool, we are unable to provide personalized assistance in designing models tailored to your specific ethno-geographic background.
You should also keep in mind that qpAdm is a relatively hard tool to use efficiently and there is no guarantee that you will achive your desired results.
You can use the raw data files from MyHeritage, Ancestry DNA, FamilyTreeDNA, 23andme or Living DNA.
The commercial file you want to use has to be an autosomal raw DNA data file in genotype format. WGS files (VCF, BAM and etc.) can't be used unless they are converted into a genotype format.
qpAdm operates based on the shared SNPs between the samples you select when creating a model. We use the AADR dataset as a base, and the number of SNPs shared between this dataset and commercial raw DNA data files will vary depending on both the company and the chip version used to sequence your DNA.
As a result, there is no definitive answer to how many SNPs will be shared—this can only be determined through extensive testing. However, you can generally expect between 100,000 and 400,000 shared SNPs in total. (This number will be proportionally reduced depending on the specific samples you choose when creating a model, as not all samples in the dataset contain the same number of SNPs.)
Despite this variation, raw DNA data files from major companies typically provide enough coverage to achieve optimal results, especially given qpAdm’s robustness with low-coverage data.
A single analysis, either FST calculation or a qpAdm model takes around 5 to 10 minutes mostly depending on the target type (using your own raw data files as targets increases the time compared to using dataset samples due to merging process).
The lenght of the duration is determined by the fact that every analysis in AdmixLab is directly computed from genotype files each time, rather than using pre-processed data like PCA coordinates.
You can still see your saved analysis and download their detailed raw outputs but you can't create new ones.
Disclaimer
This is a web browser based enviroment service for ADMIXTOOLS 2 software in compliance to GPL-3 licensing. No modifications are done to the original software.